Nanoparticles target and kill cancer stem cells that drive tumor growth

Nanoparticles target and kill cancer stem cells that drive tumor growth

Found on Science Daily

Original article is from the American Chemical Society, published June 10, 2015

“Nanoparticles Target and Kill Cancer Stem Cells That Drive Tumor Growth – American Chemical Society.” Nanoparticles Target and Kill Cancer Stem Cells That Drive Tumor Growth – American Chemical Society. American Chemical Society, 10 June 2015. Web. 12 June 2015.

Cancer

Many cancer patients survive treatment only to have the cancer reappear within a few years

These recurrences and tumor spreading are usually due to cancer stem cells that are tough to kill with conventional cancer drugs

Anti-cancer drugs can often shrink tumors but don’t kill cancer stem cells

Although these cells only make up a small part of a tumor, their resistance to drugs makes them difficult to kill and they cause significant tumor growth

Source: “Nanoparticles Target and Kill Cancer Stem Cells That Drive Tumor Growth – American Chemical Society.” Nanoparticles Target and Kill Cancer Stem Cells That Drive Tumor Growth – American Chemical Society. American Chemical Society, 10 June 2015. Web. 12 June 2015.

Experiment

The researchers packaged the anti-cancer drug doxorubicin into nanoparticles coated with chitosan (natural polysaccharide)

Once in the acidic environment of the tumor, the nanoparticles degraded and released the drug

Source: “Nanoparticles Target and Kill Cancer Stem Cells That Drive Tumor Growth – American Chemical Society.” Nanoparticles Target and Kill Cancer Stem Cells That Drive Tumor Growth – American Chemical Society. American Chemical Society, 10 June 2015. Web. 12 June 2015.

Nanoparticles in mice

The red and yellow are cancer cells in mice.

Source: http://web.1.c2.audiovideoweb.com/1c2web3536/PP061015cscHR.jpg

Results

Testing on tissue-like clumps of both normal and cancer stem cells in vitro and on human breast tumors grown in mice showed the therapy successfully killed cancer stem cells and destroyed tumors

The mice showed no obvious side-effects

Hopefully, humans will have the same success with this same treatment in the future

Source: “Nanoparticles Target and Kill Cancer Stem Cells That Drive Tumor Growth – American Chemical Society.” Nanoparticles Target and Kill Cancer Stem Cells That Drive Tumor Growth – American Chemical Society. American Chemical Society, 10 June 2015. Web. 12 June 2015.

 
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